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Curr Opin Neurobiol. 1996 Jun;6(3):324-30.

Fast actions of neurotrophic factors.

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Department of Neurochemistry, Max Planck Institute for Psychiatry, Am Klopferspitz 18a, D-82152 Martinsried, Germany.


A diversity of neurotrophic factors are required for the differentiation and survival of neurons and for maintaining their phenotype. By virtue of the rapid time scale of signal transduction in the cytosol, many of these factors also acutely regulate neuronal functions as diverse as synaptic transmission and nerve growth. These fast actions greatly expand the regulatory role of neurotrophic factors, particularly in the synaptic plasticity of developing nervous systems.

[Indexed for MEDLINE]

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