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Curr Opin Neurobiol. 1996 Feb;6(1):49-56.

Pax proteins and eye development.

Author information

1
Developmental Biology Research Centre, Kings College London, UK. UDBL061@kcl.ac.uk

Abstract

Homologous members of the Pax gene family are required for eye development in Drosophila and vertebrates. Despite superficial similarities in the phenotypes of vertebrates with mutations in pax-6 and Drosophila eyeless mutants, it remains uncertain whether the two proteins encoded by these genes have comparable functions. The genetic cascade triggered by eyeless leads to eye formation, whereas pax-6 is not necessary for optic vesicle formation, but is required at other stages of eye development. A second vertebrate Pax gene, pax-2, is also required during eye development and appears to play a role during closure of the choroid fissure.

PMID:
8794051
DOI:
10.1016/s0959-4388(96)80008-0
[Indexed for MEDLINE]

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