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Curr Opin Neurobiol. 1996 Feb;6(1):64-70.

Role of neurotrophic factors in neuronal development.

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1
INSERM U.382, Developmental Biology Institute of Marseille (IBDM), CNRS-INSERM Université de la Méditerranée, Campus de Liminy, France. chris@ibdm.univ-mrs.fr

Abstract

The spectrum of potential biological roles for neurotrophic factors in development and maturation of the nervous system continues to widen. Careful analysis of the phenotypes of knock-out mice has been used to test directly the 'neurotrophic hypothesis', and the role of members of the transforming growth factor beta superfamily--in particular, glial cell line derived neurotrophic factor--in regulating neuronal survival has become apparent. The effects of neurotrophin-3 on early neuronal differentiation and maturation have proved to be both multiple and complex. Neurotrophic factors are also emerging as potential regulators of synapse stabilization and function.

PMID:
8794045
[Indexed for MEDLINE]
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