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Curr Opin Immunol. 1996 Aug;8(4):510-6.

T-cell recognition of non-peptide antigens.

Author information

1
Division of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, MA 02115, USA.

Abstract

Studies of two distinct human T-cell systems have provided the exciting finding that T cells are able to recognize non-peptide antigens: gammadelta T cells have been shown to recognize isopentenyl pyrophosphate and related structures and human CD1 has been shown to present microbial lipids and lipoglycans such as mycolic acids and lipoarabinomannan to T cells. T-cell responses to these non-peptide antigens should provide a strategic target for immunologic intervention in infectious disease.

PMID:
8794014
DOI:
10.1016/s0952-7915(96)80039-2
[Indexed for MEDLINE]

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