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Curr Opin Immunol. 1996 Aug;8(4):517-25.

Invasion, control and persistence of Leishmania parasites.

Author information

1
Institute of Clinical Microbiology and Immunology, University of Erlangen, Wasserturmstrasse 3, D-91054 Erlangen, Germany. christian.bogdan@mikrobio.med.uni-erlangen.de

Abstract

Significant advances in research on the immunopathogenesis of leishmaniasis include the discovery of novel putative evasion and survival strategies of Leishmania parasites, a more detailed understanding of the function and regulation of interleukin-12, definition of molecules involved in cognate interaction between macrophages and T cells and new ideas concerning the mechanisms of host resistance and susceptibility. The use of transgenic mice for (re)probing certain immunological aspects of leishmaniasis has yielded not only predictable and confirmatory but also unexpected and pioneering results which require critical appreciation.

PMID:
8794010
DOI:
10.1016/s0952-7915(96)80040-9
[Indexed for MEDLINE]

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