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Curr Opin Immunol. 1996 Jun;8(3):412-8.

Phosphatidylinositol 3-kinase related kinases.

Author information

1
Department of Immunology, Mayo Clinic/Foundation, Rochester, MN 55905, USA. abraham.robert@mayo.edu

Abstract

Studies in yeast, files and mammalian cells have uncovered a novel family of signal-transducing kinases which bear an evolutionary relationship to phosphatidylinositol 3-kinase. These phosphatidylinositol 3-kinase related enzymes play critical roles in DNA repair, V(D)J recombination and cell-cycle checkpoints, and their dysfunction leads to clinical manifestations ranging from immunodeficiency to cancer.

PMID:
8793996
DOI:
10.1016/s0952-7915(96)80132-4
[Indexed for MEDLINE]

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