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Curr Opin Immunol. 1996 Jun;8(3):378-82.

Activation of B lymphocytes: integrating signals from CD19, CD22 and Fc gamma RIIb1.

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Wellcome Trust Immunology Unit, University of Cambridge, School of Clinical Medicine, UK.


Three accessory membrane proteins, CD19, CD22 and Fc gamma RIIb1, alter signaling through membrane immunoglobulin of B cells by binding cytosolic proteins containing SH2 domains. Recent biochemical and genetic studies have shown that these receptors enable B cells to amplify responses to certain T-cell-dependent antigens (CD19), to restrict their response to T-cell zones of secondary lymphoid organs (CD22), and to dampen their response to antigens for which IgG is already available (Fc gamma RIIb1).

[Indexed for MEDLINE]

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