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Curr Opin Immunol. 1996 Jun;8(3):355-61.

Role of Fas-mediated cell death in the regulation of immune responses.

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1
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA. lukvp@bustoff.bwh.harvard.edu

Abstract

Interaction of the cell-surface molecule Fas (CD95 APO-1) with its specific ligand triggers apoptotic death of T and B lymphocytes. This pathway is important for eliminating self-reactive lymphocytes and thus preventing autoimmunity. Fas is also involved in controlling injurious lymphocyte reactions in immunologically 'privileged' tissues, and may provide a strategy for reducing graft rejection.

PMID:
8793992
[Indexed for MEDLINE]
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