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Curr Biol. 1996 Jun 1;6(6):676-8.

Disease mechanism: unravelling Wiskott-Aldrich syndrome.

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1
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

The gene responsible for Wiskott-Aldrich syndrome, a disease affecting platelets and lymphocytes, has been cloned and its protein product (WASp) found to interact with the GTPase Cdc42. WASp seems to provide a link between Cdc42 and the actin cytoskeleton, perhaps explaining the cellular defects underlying the disease.

PMID:
8793292
DOI:
10.1016/s0960-9822(09)00447-3
[Indexed for MEDLINE]
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