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Brain Res Mol Brain Res. 1996 Jun;38(2):300-3.

Selective role for trkB neurotrophin receptors in rapid modulation of hippocampal synaptic transmission.

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Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854, USA.


Neurotrophins regulate neuronal survival and phenotypic differentiation. Recent evidence also suggests a role in the modulation of synaptic activity. Using neuronal cell cultures from embryonic hippocampus, we previously found that application of brain-derived neurotrophic factor rapidly enhanced synaptic transmission. We now report that application of neurotrophin-4, another ligand for the trkB neurotrophin receptor, was equally effective in enhancing synaptic currents. In contrast, nerve growth factor, neurotrophin-3, basic fibroblast growth factor and epidermal growth factor did not share this action. Our results suggest that activation of trkB receptors plays a selective role in the regulation of synaptic efficacy in the hippocampus.

[Indexed for MEDLINE]

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