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Acta Anaesthesiol Scand. 1996 May;40(5):520-3.

Reduced hypoxic chemosensitivity in partially paralysed man. A new property of muscle relaxants?

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1
Department of Anaesthesiology and Intensive Care, Karolinska Hospital and Institute, Stockholm, Sweden.

Abstract

BACKGROUND:

It was hypothesized that non-depolarizing neuromuscular blocking agents impair hypoxic chemosensitivity in man.

METHODS:

In thirty randomly allocated male volunteers the hypoxic and hypercarbic ventilatory responses were measured during partial paralysis (TOF ratio 0.70) due to either atracurium (n = 10), pancuronium (n = 10) or vecuronium (n = 10).

RESULTS:

Hypoxic ventilatory responses were depressed by 306, 287 and 296% (mean SD) at steady-state infusion of atracurium, pancuronium and vecuronium, respectively. At a TOF ratio of > 0.90, the HVR was not different from control measurements.

CONCLUSION:

It is concluded that non-depolarizing neuromuscular blocking agents impair hypoxic ventilatory regulation. Further experimental studies are warranted to fully describe the mechanism(s) responsible for this interaction.

PMID:
8792879
[Indexed for MEDLINE]
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