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Planta Med. 1996 Aug;62(4):381-2.

Active constituents against HIV-1 protease from Garcinia mangostana.

Abstract

The ethanol extract of Garcinia mangostana L. (Guttiferae) showed potent inhibitory activity against HIV-1 protease. The activity-guided purification of the extract resulted in the isolation of two active, known compounds. The chemical structures of the isolated compounds were established by spectroscopic analyses as mangostin (IC50 = 5.12 +/- 0.41 microM) and gamma-mangostin (IC50 = 4.81 +/- 0.32 microM). The type of inhibition by both compounds is noncompetitive.

PMID:
8792678
DOI:
10.1055/s-2006-957916
[Indexed for MEDLINE]
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