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Curr Opin Genet Dev. 1996 Feb;6(1):56-64.

Cdk inhibitors in development and cancer.

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1
Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030, USA. jharper@bcm.tmc.edu

Abstract

Activation of cyclin-dependent kinases is the primary control point of cell proliferation. Recent advances in the understanding of cell-cycle regulation have uncovered two families of proteins that bind and inhibit these kinases. These proteins are likely mediators of development and differentiation, and may provide molecular connections between the pathways of development and tumorigenesis.

PMID:
8791491
[Indexed for MEDLINE]
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