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Curr Opin Genet Dev. 1996 Feb;6(1):34-8.

Programmed cell death in invertebrates.

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Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.


Genetic studies of programmed cell death in Caenorhabditis elegans and Drosophila melanogaster have led to the identification of several invertebrate cell death genes. In C. elegans, ced-3 and ced-4 function to kill cells, whereas ced-9 protects cells from death. In Drosophila, the genes reaper and hid act in parallel to promote cell death. Characterization of these genes has revealed that the process of programmed cell death is evolutionarily conserved and has shed light on the molecular nature of the apoptotic machinery.

[Indexed for MEDLINE]

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