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Curr Opin Cell Biol. 1996 Aug;8(4):566-74.

Cell surface organization by the membrane skeleton.

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Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba 3-8-1, Meguro-ku, Tokyo 153, Japan.


Single-particle tracking and laser tweezers have facilitated the observation of the mechanics of molecular interactions in the plasma membrane of living cells at the level of single (or a few) molecules at nanometer/piconewton precision. These techniques have recently revealed that the membrane skeleton provides both confining and binding effects on the movement of membrane proteins, and that it can play a pivotal role in the molecular organization of the plasma membrane, especially in the formation of special membrane domains.

[Indexed for MEDLINE]

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