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Curr Opin Cell Biol. 1996 Apr;8(2):189-96.

Heterotrimeric G proteins.

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University of Illinois at Chicago, Department of Physiology and Biophysics, 835 S Wolcott, Chicago, IL 60612, USA.


Over the past year, the thrust of work in the field of heterotrimeric G proteins has been primarily in the following areas: first, resolution of their three-dimensional structures by X-ray crystallography; second, elucidation of the effect of lipid modifications on the Galpha and Ggamma subunits; third, understanding the role of the Gbetagamma dimer in stimulation of a variety of effectors following receptor activation; and fourth, identification of the points of contact among the Galpha, Gbeta, and Ggamma subunits, and between these subunits and their cognate receptor or effector molecules.

[Indexed for MEDLINE]

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