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Curr Opin Cell Biol. 1996 Apr;8(2):159-67.

Signal transduction through lipid second messengers.

Author information

1
Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20007, USA.

Abstract

This review emphasizes the generation of glycerolipid and sphingolipid second messengers, and their molecular targets. The role of the phosphatidylinositol transfer protein and phospholipase D in signal transmission, and the structures of the 1, 2-diacylglycerol and calcium-binding sites of protein kinase C are discussed. Further, ceramide signaling through protein kinases and the role of cross-talk in the signaling of apoptosis and inflammation are addressed.

PMID:
8791422
DOI:
10.1016/s0955-0674(96)80061-5
[Indexed for MEDLINE]

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