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Curr Opin Cell Biol. 1996 Apr;8(2):153-8.

Phosphoinositide kinases.

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Department of Medicine, Beth Israel Hospital, Boston, MA 02215, USA.


Recently, a number of cDNA clones with homology to the catalytic subunit of phosphoinositide 3-kinase have been identified, and the sequence of the first cDNA clone encoding a phosphatidylinositol 4-phosphate 5-kinase has been published. Use of both dominant-negative mutants of phosphoinositide 3-kinase and the inhibitors wortmannin and LY294002 has identified a number of processes in which phosphoinositide 3-kinase participates, including cell motility, the Ras pathway, vesicle trafficking and secretion, and apoptosis. Several possible biochemical targets of phosphoinositides have been found.

[Indexed for MEDLINE]

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