Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuron. 1996 Feb;16(2):275-86.

Persistent expression of genes of the enhancer of split complex suppresses neural development in Drosophila.

Author information

  • 1Institut für Entwicklungsbiologie Universität zu Köln, Germany.

Abstract

The segregation of neural and epidermal progenitors in Drosophila requires the activity of transcription factors encoded by the proneural genes and the genes of the E(SPL)-C. Persistent expression of two genes of the E(SPL)-C suppresses neural development. Embryos exhibit conspicuous central neural hypoplasia and lack sensory organs; imaginal sensory organs are also affected. Suppression of neural development is associated with suppression of the activity of proneural genes. DNA binding is not essential for this effect. Large cells with characteristics of neuroblasts segregate normally in embryos, but these cells fail to express various markers, and the segregated cells and/or their progeny eventually die. These findings indicate that proneural and E(spl) proteins exert antagonistic functions.

PMID:
8789943
[PubMed - indexed for MEDLINE]
Free full text

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk