Send to

Choose Destination
See comment in PubMed Commons below
J Dermatol Sci. 1996 Mar;11(3):250-3.

Ascorbic acid preferentially enhances type I and III collagen gene transcription in human skin fibroblasts.

Author information

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.


Ascorbic acid is a potent stimulator for type I and III collagen expression in human skin fibroblasts; stimulation of type I and III collagen synthesis and their mRNA levels by ascorbic acid has been reported previously. Nuclear run-on experiments demonstrated that ascorbic acid enhanced the transcription of type I and III collagen genes 4- and 3.4-fold respectively, whereas transcription of type IV collagen was slightly stimulated (1.7-fold). The results suggest that ascorbic acid preferentially enhanced type I and III collagen transcription.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center