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Trends Genet. 1996 Aug;12(8):306-10.

Flies on steroids--Drosophila metamorphosis and the mechanisms of steroid hormone action.

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Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112, USA.


Recent studies have provided new insights into the molecular mechanisms by which the steroid hormone ecdysone triggers the larval-to-adult metamorphosis of Drosophila. Ecdysone-induced transcription factors activate large sets of secondary-response genes and provide the competence for subsequent regulatory responses to the hormone. It seems likely that similar hormone-triggered regulatory hierarchies exist in other higher organisms and that Drosophila is providing our first glimpses of the complexities of these gene networks.

[Indexed for MEDLINE]

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