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Trends Genet. 1996 Aug;12(8):306-10.

Flies on steroids--Drosophila metamorphosis and the mechanisms of steroid hormone action.

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1
Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112, USA. carl.thummel@genetics.utah.edu

Abstract

Recent studies have provided new insights into the molecular mechanisms by which the steroid hormone ecdysone triggers the larval-to-adult metamorphosis of Drosophila. Ecdysone-induced transcription factors activate large sets of secondary-response genes and provide the competence for subsequent regulatory responses to the hormone. It seems likely that similar hormone-triggered regulatory hierarchies exist in other higher organisms and that Drosophila is providing our first glimpses of the complexities of these gene networks.

PMID:
8783940
[Indexed for MEDLINE]
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