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Immunol Today. 1996 Aug;17(8):391-7.

Strategies for expressing human antibody repertoires in transgenic mice.

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Dept of Development and Genetics, Babraham Institute, Cambridge, UK.


Repertoires of human antibodies can be created in transgenic mice carrying human immunoglobulin-gene loci in germline configuration. These 'transloci', introduced either as miniloci or as almost locus-sized regions, undergo rearrangement and hypermutation in mouse lymphoid tissue. Here, Marianne Brüggemann and Michael Neuberger review the use of such mice for raising antigen-specific human monoclonal antibodies, as well as their exploitation for studying regulatory aspects of antibody repertoire formation.

[Indexed for MEDLINE]

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