Abstract
A new cytotoxic compound 2 was isolated from a water extract of corn germ. Structural elucidation by spectroscopic data and chemical evidence fully substantiated 2 to be 11 (E)-10-oxo-11-octadecen-13-olide. Compound 2 exhibited considerably strong cytotoxic activity against various cell lines with IC50 of 0.9-2.8 micrograms/ml.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Chemical Phenomena
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Chemistry, Physical
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Drug Screening Assays, Antitumor
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Humans
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Spectrophotometry, Ultraviolet
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Tumor Cells, Cultured
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Zea mays / chemistry*
Substances
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Antineoplastic Agents, Phytogenic
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Plant Extracts