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Calcif Tissue Int. 1996 Oct;59(4):235-7.

Vitamin D receptor genotype is not associated with bone mineral density in three ethnic/regional groups.

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Department of Biochemistry and Molecular Biology, Thomas Jefferson Medical College, Philadelphia, Pennsylvania.


We report a cross-sectional study of 48 men, 56 premenopausal women, and 80 postmenopausal women who were of three ethnic/regional backgrounds: southern European (Greek, Italian), eastern European (Jewish, Polish, Hungarian), and western European (French, British). We determined bone mineral density (BMD) at four skeletal sites and assessed the vitamin D receptor (VDR) genotype by the Bsml restriction site polymorphism. Age and body mass index had significant effects on BMD by multiple regression analysis. In addition, ethnic/regional group had a significant effect on spinal BMD in premenopausal females (P = 0.014) and in males (P = 0.039). However, VDR genotype had no significant effect on BMD in any of the three study groups.

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