Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuron. 1996 Aug;17(2):353-61.

Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth.

Author information

1
Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Abstract

Peripheral nerve injury results in axonal degeneration and in phenotypic changes of the surrounding Schwann cells, whose presence is critical for nerve regeneration. Using differential screening strategies, we identified a novel protein, termed ninjurin (for nerve injury-induced protein), that is up-regulated after axotomy in neurons and in Schwann cells surrounding the distal nerve segment. Ninjurin is located on the cell surface, is capable of mediating homophilic adhesion, and promotes neurite extension of dorsal root ganglion neurons in vitro. Ninjurin is also expressed in a number of other tissues, predominantly in epithelial cells. These results suggest that ninjurin plays a role in nerve regeneration and in the formation and function of other tissues.

PMID:
8780658
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center