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Prev Med. 1996 Jan-Feb;25(1):48-50.

Chemoprevention of colon cancer by minor dietary constituents and their synthetic analogues.

Author information

1
Division of Nutritional Carcinogenesis, American Health Foundation, Valhalla, New York 10595, USA.

Abstract

Large bowel cancer is one of the leading causes of cancer deaths in the United States and other Western countries. Based on epidemiologic and mechanistic studies, preclinical studies were designed to evaluate the chemopreventive efficacy of several nonsteroidal antiinflammatory drugs (NSAIDs) and phytochemicals and their synthetic analogues in colon carcinogenesis. These studies demonstrated that NSAIDs such as piroxicam, ibuprofen, aspirin and sulindac, D,L-alpha-difluoromethylornithine, oltipraz, anethole trithione, and diallyl disulfide inhibited colon adenocarcinomas. These results provide compelling rationale to pursue clinical trials in humans.

PMID:
8778764
DOI:
10.1006/pmed.1996.0017
[Indexed for MEDLINE]

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