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J Nat Prod. 1996 May;59(5):541-3.

Antiinflammatory C-glucosyl chromone from Aloe barbadensis.

Author information

1
Department of Pharmacology, Research Imaging Center, University of Texas Health Science Center at San Antonio, 78284-7760, USA.

Abstract

A new antiinflammatory agent identified as 8-[C-beta-D-[2-O-(E)-cinnamoyl]glucopyranosyl]-2- [(R)-2-hydroxypropyl]-7-methoxy-5-methylchromone (1) has been isolated from Aloe barbadensis Miller. At a dose of 200 microg/mouse ear, 1 exhibited topical antiinflammatory activity equivalent to 200 microg/ear of hydrocortisone. There was no reduction in thymus weight caused by treatment with 1 for any of the doses tested, while 200 microg/ear of hydrocortisone resulted in a 50% decrease in thymus weight.

PMID:
8778246
DOI:
10.1021/np9601519
[Indexed for MEDLINE]

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