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J Nat Prod. 1996 May;59(5):525-7.

Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase.

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1
Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, People's Republic of China.

Abstract

An A ring-secocycloartene triterpenoid, nigranoic acid (3,4-secocycloarta-4(28),24-(Z)-diene-3,-26-dioic acid, (1) was isolated from the stems of Schisandra sphaerandra, a Chinese traditional medicinal plant. Its structure elucidation and unambiguous NMR spectral assignment were achieved by the combination of 1D- and 2D-NMR techniques with the aid of computer modeling. Nigranoic acid showed activity in several anti-HIV reverse transcriptase and polymerase assays.

PMID:
8778243
DOI:
10.1021/np960149h
[Indexed for MEDLINE]
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