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Lancet. 1996 Aug 31;348(9027):592-3.

The discrepancy in discrepant analysis.

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Centers for Disease Control and Prevention, Center for HIV, STD, and TB prevention, Atlanta, GA 30333, USA.


Discrepant analysis is a widely used technique that attempts to provide estimates of sensitivity and specificity in the presence of an imperfect gold-standard. This technique has been applied by many researchers to estimate the sensitivity and specificity of DNA-amplification tests for Chlamydia trachomatis such as the plasmid-based ligase chain-reaction and polymerase chain-reaction tests. However, the sensitivity and specificity estimates obtained by discrepant analysis are upwardly biased, and this bias remains even when a perfect test is used to resolve the discrepant results. This technique should not be adopted for evaluating the performance of a diagnostic test.

[Indexed for MEDLINE]

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