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Eur J Pharmacol. 1996 Apr 22;301(1-3):R15-6.

Reduced long-term potentiation in the dentate gyrus of mGlu1 receptor-mutant mice in vivo.

Author information

1
Pharmacology Department, Glaxo-Wellcome Research Laboratories, Verona, Italy. fb23261@ggr.co.uk

Abstract

Long-term potentiation in the dentate gyrus was studied in vivo in mutant mice lacking the metabotropic glutamate (mGlu) subtype 1 receptor. Long-term potentiation was induced in wild type animals (n = 7), but was reduced in mice lacking this receptor subtype (n = 7). These data suggest that mGlu receptors may be involved in the induction or maintenance of synaptic plasticity or that these receptors are required during development to establish this plasticity.

PMID:
8773471
DOI:
10.1016/0014-2999(96)00138-0
[Indexed for MEDLINE]

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