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Eur J Pharmacol. 1996 Apr 22;301(1-3):R11-3.

Affinities and intrinsic activities of dopamine receptor agonists for the hD21 and hD4.4 receptors.

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Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore 21228, USA. rlahti@umabnet


The affinity and intrinsic activity of dopamine receptor agonists were determined at the human dopamine hD21 and hD4.4 receptors. (-)-3-Hydroxy-N-n-propylpiperidine ((-)3-PPP) had an intrinsic activity of 46% and 83%, whereas (+)-N-propylnorapomorphine ((+)-NPA) had intrinsic activities of 61% and 58% at the dopamine hD21 and hD4.4 receptors, respectively. Affinities also varied. A single, or multiple, dopamine D2-type receptor(s) may be involved in schizophrenia and agonists are being tested as therapy. Understanding their properties at the individual dopamine D2-family receptors is important.

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