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Trends Biochem Sci. 1996 Aug;21(8):289-96.

HSP100/Clp proteins: a common mechanism explains diverse functions.

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Howard Hughes Medical Institute, Chicago, IL, USA.


The HSP100/Clp proteins are a newly discovered family with a great diversity of functions, such as increased tolerance to high temperatures, promotion of proteolysis of specific cellular substrates and regulation of transcription. HSP100/Clp proteins are also synthesized in a variety of specific patterns and, in eukaryotes, are localized to different subcellular compartments. Recent data suggest that a common ability to disassemble higher-order protein structures and aggregates unifies the molecular functions of this diverse family.

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