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Genetics. 1996 Jan;142(1):163-71.

Mutations Modulating Raf signaling in Drosophila eye development.

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1
Zoologisches Institut, Universität Zũrich, Switzerland.

Abstract

The R7 fate is specified during Drosophila eye development by an inductive signal transduced intracellularly via the Raf kinase. We have performed a genetic screen for dominant mutations that alter the efficiency with which cells respond to a constitutively activated Raf kinase. Such mutations may affect genes involved in signal transduction downstream of Raf. We have isolated 44 mutations that define eight genes. One of these encodes a mitogen-activated protein kinase homologue: another is a putative target gene of this signaling pathway. We present the results of this screen in detail, as well as a preliminary genetic analysis of the six loci still to be characterized molecularly.

PMID:
8770593
PMCID:
PMC1206944
[Indexed for MEDLINE]
Free PMC Article
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