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Phytochemistry. 1996 Jun;42(3):637-9.

Nonsterol related resistance in Ustilago maydis to the polyene antifungals, amphotericin B and nystatin.

Author information

1
Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, U.K.

Abstract

Two amphotericin B resistant mutants of Ustilago maydis were isolated following direct selection from a wild-type population. Each mutant was demonstrated to be cross-resistant to nystatin yet remained sensitive to azoles. Sterol analysis indicated a sterol profile similar to the parent strain, precluding the involvement of an alteration in ergosterol biosynthesis as the cause of polyene resistance.

PMID:
8768319
DOI:
10.1016/0031-9422(96)00037-4
[Indexed for MEDLINE]

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