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Eur J Immunol. 1996 Aug;26(8):1830-7.

Sequential antigen-specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c.

Author information

1
Department of Immunology, University of Birmingham Medical School, GB.

Abstract

The sites of accumulation and growth of antigen-specific T cells was assessed during the V alpha 11/V beta 3 T cell receptor-restricted response of IEk+ mice to pigeon cytochrome c. In the T zone, the response was early but transient; V alpha 11/V beta 3+ T cell numbers fell to background levels as germinal centers developed. The follicles were a major site of specific T cell growth, but V alpha 11/V beta 3+ T cells were not obvious in foci of extrafollicular B cell growth in the red pulp. As germinal centers waned, V alpha 11/V beta 3+ T cells in the T zones again rose above background levels and some persisted in the follicles. After the initial stage of T cell priming, specific T cell growth seems to occur where specific interaction can occur with B cells that are presenting processed antigen.

PMID:
8765028
DOI:
10.1002/eji.1830260825
[Indexed for MEDLINE]

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