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Eur J Immunol. 1996 Aug;26(8):1781-7.

Association of phosphatidylinositol 3 kinase to protein kinase C zeta during interleukin-2 stimulation.

Author information

1
Centro Nacional de Biotecnología, Universidad Autónoma, Madrid, Spain.

Abstract

Interleukin-2 induces a serine-phosphorylated phosphatidylinositol 3 kinase activity in the mouse T cell line TS1 alpha beta. Moreover, protein kinase C (PKC) zeta directly or indirectly associates with the phosphatidylinositol 3 kinase and the association appears to be necessary for the serine-phosphorylated phosphatidylinositol 3 kinase activity, since release of zeta PKC by competition of binding with peptides spanning the p110 sequence from amino acids 907 to 925 abolishes the serine-phosphorylated phosphatidylinositol 3 kinase activity. This kinase activity is also blocked when zeta PKC expression is inhibited by antisense oligonucleotide. Inhibition of phosphatidylinositol 3 kinase activity by wortmannin does not abolish zeta PKC association.

PMID:
8765021
DOI:
10.1002/eji.1830260818
[Indexed for MEDLINE]

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