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Life Sci. 1996;59(4):PL61-8.

Effect of glycosylation on cloned ANF-sensitive guanylyl cyclase.

Author information

1
Abteilung für Klinische Pharmakologie, Klinikum Innenstadt der Universität, München, Germany.

Abstract

Cloned ANF-sensitive guanylyl cyclase (GC-A) and ANF-sensitive guanylyl cyclase from adrenal cortex differ in their sensitivity to the ANF analogs atriopeptin 1 and urodilatin. To test the hypothesis that these differences are due to different glycosylation, we investigated the effect of the N-glycosylation inhibitor tunicamycin on GC-A. Tunicamycin altered the response of GC-A to atriopeptin 1 and urodilatin, whereas the sensitivity to ANF remained unchanged. These data indicate that agonist specificities of different ANF-sensitive guanylyl cyclases are influenced by carbohydrate moieties.

PMID:
8761009
DOI:
10.1016/0024-3205(96)00306-2
[Indexed for MEDLINE]

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