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J Allergy Clin Immunol. 1996 Aug;98(2):408-11.

Histamine and leukotriene C4 release in cutaneous mosquito-bite reactions.

Author information

1
Department of Dermatology, Kuopio University Hospital, Finland.

Abstract

BACKGROUND:

Mosquito bites are known to sensitize persons, and the most common cutaneous reactions are immediate wheals and delayed bite papules. Anti-saliva IgE and IgG4 antibodies are common in mosquito-sensitive subjects, but mediator release in bite reactions is not known.

METHODS:

We used the microdialysis technique to measure in vivo histamine and leukotriene C4 release after bite challenges in six mosquito-sensitive subjects. One individual who was not sensitive to bites volunteered as a control subject.

RESULTS:

Three of the six mosquito-sensitive subjects had large wheals and showed clearly increased histamine concentrations 30 to 45 minutes after the bites. The histamine levels declined to baseline value within 2 hours; thereafter, one subject showed a second increase in histamine concentration. Four of the six mosquito-sensitive subjects showed increased leukotriene C4 concentrations, and this mediator seemed to be released somewhat later than histamine.

CONCLUSIONS:

The increased histamine and leukotriene C4 release observed in this study suggests that both mediators are involved in the early allergic response caused by mosquito bites.

PMID:
8757218
[Indexed for MEDLINE]

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