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Nature. 1996 Aug 15;382(6592):595-601.

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer.

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1
Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, 90095-1737, USA.

Abstract

An abundant cDNA enriched in Spemann's organizer, cerberus, was isolated by differential screening. It encodes a secreted protein that is expressed in the anterior endomesoderm. Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads, and duplicated hearts and livers. The results suggest a role for a molecule expressed in the anterior endoderm in the induction of head structures in the vertebrate embryo.

PMID:
8757128
DOI:
10.1038/382595a0
[Indexed for MEDLINE]
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