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Trends Pharmacol Sci. 1996 Jul;17(7):264-9.

The stimulatory effects of opioids and their possible role in the development of tolerance.

Author information

1
Parke-Davis Neuroscience Research Centre, Cambridge University, UK.

Abstract

Opioids have stimulatory as well as the traditional inhibitory effects on neurotransmission, but the underlying mechanisms are poorly understood. Here, Darren Smart and David Lambert review the stimulatory effects of opioids on second messengers, including inositol (1,4,5)-trisphosphate (IP3), protein kinase C (PKC), Ca2+, and cAMP, and propose that these coordinated changes at the cellular level underlie the facilitatory effects of opioids on neurotransmission. The evidence for a possible role for these stimulatory effects, particularly the activation of PKC by opioids, in the development of tolerance is also discussed.

PMID:
8756186
DOI:
10.1016/0165-6147(96)10023-7
[Indexed for MEDLINE]

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