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Trends Biochem Sci. 1996 Jul;21(7):237-41.

CPx-type ATPases: a class of P-type ATPases that pump heavy metals.

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Department of Clinical Pharmacology, University of Berne, Switzerland.


ATP-driven heavy metal pumps represent a newly defined class of proteins that translocate toxic and essential metals across biological membranes. These transporters form a separate evolutionary branch of the ion-transporting P-type ATPases. We propose to call these enzymes CPx-type ATPases, based on the common novel feature of a conserved intramembranous cysteine-proline-cysteine or cysteine-proline-histidine motif.

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