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Zh Vyssh Nerv Deiat Im I P Pavlova. 1996 May-Jun;46(3):547-51.

[The effect of serotonin on the cross-correlation of neuronal activity in surviving cortical slices].

[Article in Russian]


Serotonin-induced changes in crosscorrelation functions of the trains of neuronal activity were studied in surviving slices of the guinea pig cerebral cortex. After serotonin administration into the incubation medium and its washing-out the value of the crosscorrelation function in the zero bin increased as compared with its initial value if the background impulsation rate of both neurons was high and decreased if the background rate was low. This finding substantiates the earlier advanced hypothesis that serotoninergic system is related to the positive reinforcement in learning and influences the efficiency of the cortico-cortical synapses increasing it when the initial excitation of the presynaptic neuron is high and decreasing when the background presynaptic excitation level is low.

[Indexed for MEDLINE]

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