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Zh Vyssh Nerv Deiat Im I P Pavlova. 1996 May-Jun;46(3):504-12.

[The effect of anterior lesions to the medial forebrain bundle on the motor activity evoked by a sensory deficit (sensory drive) in rats].

[Article in Russian]

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Medical Center for Postgraduate Education, Nencki Institute of Experimental Biology, Wrasaw, Poland.


The orbito-frontal cortex and postcommissural MFB lesions evoked two major effects. The first one consisted in an increased need for light stimulation while the second one concerned changes in anxiety level with different results depending on the lesion location (cortical ot subcortical). The second effect is in agreement with P. Simonov's hypothesis concerning the different configurations of the CNS structures. Upon destruction of the orbito-frontal area, the dominant role in behaviour regulation is taken over by the "emotional part" of the brain, whereas the destruction of the postcommissural MFB (reduction of the amygdalar influence on the hypothalamus) creates conditions for functional prevalence of the "informational brain".

[Indexed for MEDLINE]

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