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Genetika. 1996 May;32(5):709-15.

[Criterion quality and estimation of the expected sample size in sequential analysis of linkage].

[Article in Russian]


It is shown that, when conducting sequential testing of linkage in pedigree samples, (1) type I and type II errors observed are less than expected and (2) the generally accepted method for determining the average sample size, E(N), required for sequential analysis of linkage, underestimates it. A less biased approximation of E(N) is proposed. A wide scattering of actual sample sizes required for completion of sequential analysis is demonstrated, which puts practical use of E(N) into question.

[PubMed - indexed for MEDLINE]
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