Format

Send to

Choose Destination
Fertil Steril. 1996 Sep;66(3):430-4.

The effect of antioxidant treatment on human spermatozoa and fertilization rate in an in vitro fertilization program.

Author information

1
Serlin Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.

Abstract

OBJECTIVE:

To study the possible influence of antioxidant treatment on human spermatozoa and the fertilization rate in an IVF program.

DESIGN:

Prospective study.

SETTING:

In Vitro Fertilization Unit, Serlin Maternity Hospital, and the Laboratory of Male Fertility, Bar-Ilan University, Ramat-Gan, Israel.

PATIENTS:

Fifteen fertile normospermic male volunteers who had low fertilization rates in their previous IVF cycles.

INTERVENTIONS:

Vitamin E (alpha-tocopherol) 200 mg daily by mouth for 3 months.

MAIN OUTCOME MEASURES:

Lipid peroxidation potential (amount of malondialdehyde [MDA]), quantitative ultramorphologic analysis of spermatozoa, and fertilization rate per cycle.

RESULTS:

The high MDA levels significantly decreased from 12.6 +/- 9.4 nmol/10(8) spermatozoa to normal levels of 7.8 +/- 4.2 nmol/10(8) spermatozoa after 1 month of treatment. The fertilization rate per cycle increased significantly from 19.3 +/- 23.3 to 29.1 +/- 22.2 after 1 month of treatment. No additional effects on MDA levels and fertilization rate were observed after completion of treatment. With regard to the quantitative ultramorphologic analysis, none of the sperm cell subcellular organelles were affected significantly by vitamin E treatment.

CONCLUSION:

Vitamin E may improve the fertilization rate of fertile normospermic males with low fertilization rates after 1 month of treatment, possibly by reducing the lipid peroxidation potential, and with no change of the quantitative ultramorphologic analysis of subcellular organelles.

PMID:
8751743
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center