Send to

Choose Destination
J Affect Disord. 1995 Dec 13;35(3):139-43.

Neuroticism: a vulnerability marker for depression evidence from a family study.

Author information

University of Nottingham Department of Psychiatry, Mapperley Hospital, UK.



We investigated the relationship between depressive illness and personality traits from the Eysenck Personality Inventory (EPI) using data from a family study.


The first-degree relatives of a series of 89 probands with RDC major depression (MD) were subdivided by their lifetime RDC diagnosis into: (1) relatives recovered from MD (n = 34); (2) never-ill relatives (n = 45). The neuroticism (N) and extraversion (E) scores of these two groups were compared using a multilevel linear model, allowing for potential confounders. The relationship between age of onset and recurrence of MD and N scores in group 1 was also examined.


(1) Raised N scores were associated with a past history of major depression. (2) There was no such relationship for E scores. (3) Current depressive symptoms were also associated with an increased N score but this did not explain the relationship between previous major depression and N scores. (4) Recurrent episodes of major depression in the recovered MD relatives were significantly associated with increased N scores.


These data suggest that raised N may be a vulnerability marker for major depression.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center