Format

Send to

Choose Destination
Clin Infect Dis. 1995 Dec;21(6):1485-7.

Treatment of cerebral Aspergillosis with itraconazole: do high doses improve the prognosis?

Author information

1
Department of Internal Medicine and Infectious Diseases, University of Barcelona, Terrassa, Spain.

Abstract

We describe a 72-year-old woman with chronic asthma who presented with cerebral abscesses due to Aspergillus fumigatus after she received treatment with corticosteroids. Therapy with high-dose itraconazole (800 mg/d for 5 months, followed by 400 mg/d for an additional 4.5 months) resulted in complete resolution of all lesions. Serum concentrations of the drug ranged from 2 micrograms/mL to 30 micrograms/mL. Review of 20 cases of cerebral aspergillosis that were treated with itraconazole revealed that three of the four patients who received high doses (800 mg/d in the adults) of the drug responded favorably, while only two of the 16 patients who received a dose of 400 mg/d were cured. The use of high-dose itraconazole appears to be justified for high-risk patients with cerebral aspergillosis for whom conventional therapy has failed.

PMID:
8749640
DOI:
10.1093/clinids/21.6.1485
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center