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Immunobiology. 1995 Nov;194(4-5):443-48.

Cleavage of the third component of complement (C3) by mannose-binding protein-associated serine protease (MASP) with subsequent complement activation.

Author information

1
Department of Biochemistry, Fukushima Medical College, Japan.

Abstract

We have previously shown that a novel C1s-like serine protease termed MBP-associated serine protease (MASP) is responsible for activation of the complement cascade initiated by mannose-binding protein (MBP). In this communication, we report that MASP is unique in having the proteolytic capacity to cleave C3 with subsequent activation of the alternative pathway, a capacity which C1s lacks.

PMID:
8749236
DOI:
10.1016/S0171-2985(11)80110-5
[Indexed for MEDLINE]

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