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Psychiatr Clin North Am. 1995 Dec;18(4):727-43.

Primate models of anxiety. Longitudinal perspectives.

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Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA.


In summary, VFD subjects appear to have sustained long-term behavioral and biologic sequelae following disruption of normative maternal-infant attachment patterns. The sequelae are primarily manifest as stable anxiety or affective traits and, from a biologic perspective, are most analogous to recent data that have emerged from studies of patients with PTSD. Multiple abnormalities are observed of systems directly involved in affect regulation. Further studies are required to clarify the pathologic ontogeny of the VFD condition and its potential relevance to human psychopathology.

[Indexed for MEDLINE]

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